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Infrastructure Innovation for Biological Research (Innovation)

U.S. National Science Foundation · Opportunity number 23-578

View the official notice on Grants.gov
18254 days left (deadline Oct 7, 2076)

Details summarized from the official notice as of Oct 16, 2026. Always confirm eligibility, deadlines and requirements in the official notice before applying.

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Key facts

Opportunity number23-578
AgencyU.S. National Science Foundation
Assistance listing (ALN, formerly CFDA)47.074
PostedApr 21, 2023
DeadlineOct 7, 2076
Award ceiling$800,000
Award floor$300,000
Expected number of awards40
Estimated total program funding$18,000,000
Cost sharing or matching requiredNo
Funding typeGrant
CategoryScience technology and other research and development
Last updated hereOct 16, 2026

Summary from the notice

The Infrastructure Innovation for Biological Research Program (Innovation) supports research to design novel or greatly improved research tools and methods that advance contemporary biology in any research area supported by the Directorate forBiological Sciences at NSF. The Innovation Program focuses on research infrastructure that is broadly applicable to researchers in three programmatic areas: Bioinformatics, Instrumentation, and Research Methods. Infrastructure supported by this program is expected to advance biological understanding by improving scientists’ abilities to manipulate, control, analyze, or measure critical aspects of biological systems, which can be essential for addressing important fundamental research questions. Proposals submitted to these programmatic areas can do one of three things to advance or transform research in biology: develop novel infrastructure, significantly redesign existing infrastructure, or adapt existing infrastructure in novel ways. Projects are expected to have a significant application to one or more biological science questions and have the potential to be used by a community of researchers beyond a single research team. Please refer to the descriptions of individual programmatic areas for detailed guidance on what is supported through this solicitation (see links below).

Who can apply

The official notice lists these applicant types as eligible:

  • Others named in the notice (see the eligibility text)

Not listed as eligible

  • Small businesses
  • Nonprofits
  • Colleges and universities
  • State governments
  • Local governments
  • Tribal governments and organizations
  • Larger for-profit companies
  • Individuals

Unless the eligibility text in the notice names you, this opportunity is probably not for you.

Eligibility details from the notice

*Who May Submit Proposals: Proposals may only be submitted by the following: -Non-profit, non-academic organizations: Independent museums, observatories, research laboratories, professional societies and similar organizations located in the U.S. that are directly associated with educational or research activities. -Institutions of Higher Education (IHEs): Two- and four-year IHEs (including community colleges) accredited in, and having a campus located in the US, acting on behalf of their faculty members. Special Instructions for International Branch Campuses of US IHEs: If the proposal includes funding to be provided to an international branch campus of a US institution of higher education (including through use of sub-awards and consultant arrangements), the proposer must explain the benefit(s) to the project of performance at the international branch campus, and justify why the project activities cannot be performed at the US campus. *Who May Serve as PI: There are no restrictions or limits.

Registrations you will likely need

Most applications submitted through Grants.gov need the following. Registration can take several weeks, so start early. The notice lists the exact requirements.

Past awards for this program

Totals for assistance listing 47.074 from public USASpending.gov data, as of Sep 23, 2026. Past awards do not predict future funding.

YearListingAwardsTotalAverage
2026 47.074 7 $187,602,317 $26,800,331
2025 47.074 6 $175,835,355 $29,305,893
2024 47.074 6 $201,363,355 $33,560,559

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