Open federal grants for for-profit businesses
395 open opportunities as of Oct 16, 2026.
Independent platform. Not affiliated with or endorsed by any government agency. Data from public federal sources.
Some federal notices are open to for-profit organizations of any size. These are listed separately from small businesses on Grants.gov. A program that lists only "small businesses" is not open to larger companies.
The list below shows every open opportunity in our database whose official notice lists for-profit businesses as an eligible applicant type. Each listing links to a summary page and to the official notice.
Being in an eligible group is only the first check. Read the eligibility section of each notice for location, program focus, cost sharing and other conditions before you start an application.
Open opportunities
Occupational Safety and Health Education and Research Centers (T42)
Centers for Disease Control and Prevention - ERA · RFA-OH-25-002
Occupational Safety and Health Training Project Grants (T03)
Centers for Disease Control and Prevention - ERA · RFA-OH-25-003
Data Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative U24 Clinical Trial Required)
National Institutes of Health · PAR-27-013
Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required)
National Institutes of Health · PAR-27-012
Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required)
National Institutes of Health · PAR-27-011
Early Immune System Development and Ontogeny (R01 Clinical Trial Optional)
National Institutes of Health · PAR-25-362
CCRP Initiative: Promoting a Basic Understanding of Chemical Threats to Skin (R01 Clinical Trial Not Allowed)
National Institutes of Health · PAR-27-075
Limited Competition: Small Grant Program for NHLBI K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)
National Institutes of Health · RFA-HL-27-004
Community-Based Participatory Research to Advance Data and Practice Transformation (ADAPT) for Optimizing Oral Health for All (UG3/UH3 Clinical Trial Optional)
National Institutes of Health · PAR-27-015
The Metastasis Research Network (MetNet): MetNet Research Projects (U01 Clinical Trial Not Allowed)
National Institutes of Health · PAR-26-134
Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
National Institutes of Health · PA-26-001
Limited Competition: Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed)
National Institutes of Health · PAR-27-067
Biomedical Technology Optimization and Dissemination Center (BTOD) (RM1 - Clinical Trial Not Allowed)
National Institutes of Health · PAR-27-024
Maximizing Investigators’ Research Award (MIRA) for Early Stage Investigators (ESI)
National Institutes of Health · PAR-27-032
BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R01 Clinical Trial Not Allowed)
National Institutes of Health · RFA-NS-28-010
HEAL Initiative: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional)
National Institutes of Health · RFA-DA-27-016
HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
National Institutes of Health · RFA-NS-27-007
NIAMS P30 Centers Program (P30 - Clinical Trial Not Allowed)
National Institutes of Health · RFA-AR-28-001
Research Grants in Clinical Informatics (R01 Clinical Trial Optional)
National Institutes of Health · PAR-26-042
Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional)
National Institutes of Health · PAR-26-040
Frequently asked questions
Does being listed as eligible mean my organization qualifies?
No. The applicant type is only the first filter. Most notices add more conditions, such as location, program focus, matching funds or prior experience. Read the eligibility section of the official notice before you apply.
Is GovGrantsUSA a government website?
No. GovGrantsUSA is an independent platform operated by VRLY Ventures LLC. It is not affiliated with or endorsed by any government agency. Opportunity details are summarized from public federal sources such as Grants.gov.
Does it cost anything to apply for a federal grant?
Searching for and applying to federal grants on Grants.gov is free. Be wary of anyone who asks for a fee to "release" a grant or guarantees an award.
How current is this information?
Listings are refreshed from public federal data every day, and each page shows when it was last updated. Agencies can change or cancel a notice at any time, so always confirm details in the official notice.
What do I need before I can apply?
Most applicants through Grants.gov need an active SAM.gov registration with a Unique Entity ID (UEI), a Login.gov account and a Grants.gov account linked to their organization. Registration can take several weeks, so start early.