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Closed on May 12, 2026

Technology Development Research for Establishing Feasibility and Proof of Concept (R21 - Clinical Trial Not Allowed)

National Institutes of Health · Opportunity number PAR-25-202

Details summarized from the official notice as of May 13, 2026. Always confirm eligibility, deadlines and requirements in the official notice before applying.

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This opportunity is closed as of May 12, 2026. It is kept here for reference. See the related open opportunities below, or check the official listing in case the agency posts a new cycle.

Key facts

Opportunity numberPAR-25-202
AgencyNational Institutes of Health
Department of Health and Human Services
Assistance listing (ALN, formerly CFDA)93.859
PostedNov 14, 2024
DeadlineMay 12, 2026
Cost sharing or matching requiredNo
Funding typeGrant
CategoryHealth
Last updated hereMay 13, 2026

Summary from the notice

This Notice of Funding Opportunity (NOFO)supports exploratory research leading to proof of concept for the development of new technologies relevant to the NIGMS mission. Projects should entail a high degree of risk and/or novelty, and have a high future potential impact in biomedical research.

Who can apply

The official notice lists these applicant types as eligible:

  • Other Native American tribal organizations
  • For-profit organizations other than small businesses
  • Nonprofits without 501(c)(3) status (other than colleges)
  • State governments
  • Others named in the notice (see the eligibility text)
  • County governments
  • Independent school districts
  • Special district governments
  • Public and state colleges and universities
  • Public and Indian housing authorities
  • Private colleges and universities
  • Nonprofits with 501(c)(3) status (other than colleges)
  • Small businesses
  • City or township governments
  • Federally recognized tribal governments

Who should take a closer look

  • Small businesses
  • Nonprofits
  • Colleges and universities
  • State governments
  • Local governments
  • Tribal governments and organizations
  • Larger for-profit companies

Not listed as eligible

  • Individuals

Unless the eligibility text in the notice names you, this opportunity is probably not for you.

Eligibility details from the notice

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Registrations you will likely need

Most applications submitted through Grants.gov need the following. Registration can take several weeks, so start early. The notice lists the exact requirements.

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