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Closed on Sep 4, 2026

Investigator Initiated Innovation in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed)

National Institutes of Health · Opportunity number PAR-25-229

Details summarized from the official notice as of Sep 5, 2026. Always confirm eligibility, deadlines and requirements in the official notice before applying.

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This opportunity is closed as of Sep 4, 2026. It is kept here for reference. See the related open opportunities below, or check the official listing in case the agency posts a new cycle.

Key facts

Opportunity numberPAR-25-229
AgencyNational Institutes of Health
Department of Health and Human Services
Assistance listing (ALN, formerly CFDA)93.172, 93.879
PostedNov 18, 2024
DeadlineSep 4, 2026
Cost sharing or matching requiredNo
Funding typeGrant
CategoryHealth
Last updated hereSep 5, 2026

Summary from the notice

The purpose of this funding opportunity announcement (FOA) is to invite applications for a broad range of research efforts in computational genomics, data science, statistics, and bioinformatics relevant to one or both of basic or clinical genomic science, and broadly applicable to human health and disease. This FOA supports fundamental genomics research developing innovative analytical methodologies and approaches, early-stage development of tools and software, and refinement or hardening of software and tools of high value to the biomedical genomics community. Work supported under this FOA should be enabling for genomics and be generalizable or broadly applicable across diseases and biological systems. All applications should address how the methods would scale to address increasingly larger data sets.

Who can apply

The official notice lists these applicant types as eligible:

  • State governments
  • Small businesses
  • Independent school districts
  • Public and state colleges and universities
  • Nonprofits without 501(c)(3) status (other than colleges)
  • For-profit organizations other than small businesses
  • Other Native American tribal organizations
  • Nonprofits with 501(c)(3) status (other than colleges)
  • Others named in the notice (see the eligibility text)
  • City or township governments
  • Public and Indian housing authorities
  • Federally recognized tribal governments
  • Special district governments
  • Private colleges and universities
  • County governments

Who should take a closer look

  • Small businesses
  • Nonprofits
  • Colleges and universities
  • State governments
  • Local governments
  • Tribal governments and organizations
  • Larger for-profit companies

Not listed as eligible

  • Individuals

Unless the eligibility text in the notice names you, this opportunity is probably not for you.

Eligibility details from the notice

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Registrations you will likely need

Most applications submitted through Grants.gov need the following. Registration can take several weeks, so start early. The notice lists the exact requirements.

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