Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)
National Institutes of Health · Opportunity number PAR-25-442
Details summarized from the official notice as of Oct 15, 2026. Always confirm eligibility, deadlines and requirements in the official notice before applying.
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Key facts
| Opportunity number | PAR-25-442 |
|---|---|
| Agency | National Institutes of Health Department of Health and Human Services |
| Assistance listing (ALN, formerly CFDA) | 93.350, 93.121, 93.867, 93.855, 93.865, 93.242 |
| Posted | Jun 17, 2025 |
| Deadline | Feb 17, 2028 |
| Cost sharing or matching required | No |
| Funding type | Grant |
| Category | Health |
| Last updated here | Oct 15, 2026 |
Summary from the notice
Who can apply
The official notice lists these applicant types as eligible:
- Nonprofits with 501(c)(3) status (other than colleges)
- City or township governments
- Small businesses
- Public and Indian housing authorities
- Public and state colleges and universities
- For-profit organizations other than small businesses
- Others named in the notice (see the eligibility text)
- Special district governments
- Independent school districts
- Federally recognized tribal governments
- State governments
- County governments
- Other Native American tribal organizations
- Nonprofits without 501(c)(3) status (other than colleges)
- Private colleges and universities
Who should take a closer look
- Small businesses
- Nonprofits
- Colleges and universities
- State governments
- Local governments
- Tribal governments and organizations
- Larger for-profit companies
Not listed as eligible
- Individuals
Unless the eligibility text in the notice names you, this opportunity is probably not for you.
Eligibility details from the notice
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Registrations you will likely need
Most applications submitted through Grants.gov need the following. Registration can take several weeks, so start early. The notice lists the exact requirements.
- SAM.gov registration for your organization, which also gives you a Unique Entity ID (UEI). Registration is free.
- A Login.gov account, which Grants.gov uses for sign-in.
- A Grants.gov applicant registration linked to your organization's UEI.
Past awards for this program
Totals for assistance listing 93.350, 93.121, 93.867, 93.855, 93.865, 93.242 from public USASpending.gov data, as of Mar 26, 2026. Past awards do not predict future funding.
| Year | Listing | Awards | Total | Average |
|---|---|---|---|---|
| 2026 | 93.855 | 1 | $1,062,954,652 | $1,062,954,652 |
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