Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)
National Institutes of Health · Opportunity number PAR-25-446
Details summarized from the official notice as of Oct 15, 2026. Always confirm eligibility, deadlines and requirements in the official notice before applying.
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Key facts
| Opportunity number | PAR-25-446 |
|---|---|
| Agency | National Institutes of Health Department of Health and Human Services |
| Assistance listing (ALN, formerly CFDA) | 93.279 |
| Posted | Sep 10, 2025 |
| Deadline | Aug 21, 2028 |
| Award ceiling | $3,000,000 |
| Cost sharing or matching required | No |
| Funding type | Cooperative agreement |
| Category | Education |
| Last updated here | Oct 15, 2026 |
Summary from the notice
Who can apply
The official notice lists these applicant types as eligible:
- City or township governments
- Public and Indian housing authorities
- Nonprofits with 501(c)(3) status (other than colleges)
- State governments
- Federally recognized tribal governments
- County governments
- For-profit organizations other than small businesses
- Public and state colleges and universities
- Special district governments
- Independent school districts
- Nonprofits without 501(c)(3) status (other than colleges)
- Other Native American tribal organizations
- Others named in the notice (see the eligibility text)
- Small businesses
- Private colleges and universities
Who should take a closer look
- Small businesses
- Nonprofits
- Colleges and universities
- State governments
- Local governments
- Tribal governments and organizations
- Larger for-profit companies
Not listed as eligible
- Individuals
Unless the eligibility text in the notice names you, this opportunity is probably not for you.
Eligibility details from the notice
Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.
Registrations you will likely need
Most applications submitted through Grants.gov need the following. Registration can take several weeks, so start early. The notice lists the exact requirements.
- SAM.gov registration for your organization, which also gives you a Unique Entity ID (UEI). Registration is free.
- A Login.gov account, which Grants.gov uses for sign-in.
- A Grants.gov applicant registration linked to your organization's UEI.
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