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Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed)

National Institutes of Health · Opportunity number PAR-27-021

View the official notice on Grants.gov
624 days left (deadline Jul 1, 2028)

Details summarized from the official notice as of Oct 15, 2026. Always confirm eligibility, deadlines and requirements in the official notice before applying.

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Key facts

Opportunity numberPAR-27-021
AgencyNational Institutes of Health
Department of Health and Human Services
Assistance listing (ALN, formerly CFDA)93.855, 93.310, 93.351, 93.866
PostedJun 25, 2026
DeadlineJul 1, 2028
Award ceiling$400,000
Award floor$50,000
Cost sharing or matching requiredNo
Funding typeGrant
CategoryHealth
Last updated hereOct 15, 2026

Summary from the notice

This Notice of Funding Opportunity (NOFO) aims to build new research capacity and develop a sustainable research program by supporting the purchase of a single commercially available biomedical research instrument currently unavailable in the institution. Instruments funded through this program must be shared among the users to create new research opportunities, enable reproducible data generation, encourage collaborative research and training, and strengthen long-term research capabilities. The minimum award is $50,000. While there is no limit on the total cost of the instrument, the maximum award is $400,000.

Who can apply

The official notice lists these applicant types as eligible:

  • City or township governments
  • Small businesses
  • Nonprofits without 501(c)(3) status (other than colleges)
  • Private colleges and universities
  • Independent school districts
  • Other Native American tribal organizations
  • County governments
  • Public and state colleges and universities
  • Public and Indian housing authorities
  • For-profit organizations other than small businesses
  • Others named in the notice (see the eligibility text)
  • Federally recognized tribal governments
  • State governments
  • Nonprofits with 501(c)(3) status (other than colleges)
  • Special district governments

Who should take a closer look

  • Small businesses
  • Nonprofits
  • Colleges and universities
  • State governments
  • Local governments
  • Tribal governments and organizations
  • Larger for-profit companies

Not listed as eligible

  • Individuals

Unless the eligibility text in the notice names you, this opportunity is probably not for you.

Eligibility details from the notice

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Registrations you will likely need

Most applications submitted through Grants.gov need the following. Registration can take several weeks, so start early. The notice lists the exact requirements.

Past awards for this program

Totals for assistance listing 93.855, 93.310, 93.351, 93.866 from public USASpending.gov data, as of Mar 26, 2026. Past awards do not predict future funding.

YearListingAwardsTotalAverage
2026 93.855 1 $1,062,954,652 $1,062,954,652

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