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Bioengineering Research Grants (BRG) (R01 Clinical Trial Optional)

National Institutes of Health · Opportunity number PAR-27-072

View the official notice on Grants.gov
993 days left (deadline Jul 5, 2029)

Details summarized from the official notice as of Oct 15, 2026. Always confirm eligibility, deadlines and requirements in the official notice before applying.

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Key facts

Opportunity numberPAR-27-072
AgencyNational Institutes of Health
Department of Health and Human Services
Assistance listing (ALN, formerly CFDA)93.395, 93.393, 93.853, 93.396, 93.399, 93.867, 93.865, 93.394
PostedMay 4, 2026
DeadlineJul 5, 2029
Award ceiling$500,000
Cost sharing or matching requiredNo
Funding typeGrant
CategoryHealth
Last updated hereOct 15, 2026

Summary from the notice

This Notice of Funding Opportunity (NOFO) encourages collaborations between the life and physical sciences that: 1) apply a multidisciplinary bioengineering approach to the solution of a biomedical problem; and 2) integrate, optimize, validate, translate or otherwise accelerate the adoption of promising tools, methods, and techniques for a specific research or clinical problem in basic, translational, or clinical science and practice. An application may propose design-directed, developmental, discovery-driven, or hypothesis-driven research and is appropriate for small teams applying an integrative approach to increase our understanding of and solve problems in biological, clinical, or translational science. This NOFO will support clinical trials that test functionality or validate performance in the chosen setting. This NOFO is not intended to support conventional clinical trials that lack translation as the primary motivation. Applications that propose phase III clinical trials in any area of research are not sought by and will not be supported through this NOFO. This NOFO does not support commercial production.

Who can apply

The official notice lists these applicant types as eligible:

  • County governments
  • For-profit organizations other than small businesses
  • Special district governments
  • Independent school districts
  • Federally recognized tribal governments
  • Nonprofits with 501(c)(3) status (other than colleges)
  • State governments
  • Public and state colleges and universities
  • Other Native American tribal organizations
  • Nonprofits without 501(c)(3) status (other than colleges)
  • Others named in the notice (see the eligibility text)
  • Public and Indian housing authorities
  • City or township governments
  • Small businesses
  • Private colleges and universities

Who should take a closer look

  • Small businesses
  • Nonprofits
  • Colleges and universities
  • State governments
  • Local governments
  • Tribal governments and organizations
  • Larger for-profit companies

Not listed as eligible

  • Individuals

Unless the eligibility text in the notice names you, this opportunity is probably not for you.

Eligibility details from the notice

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Registrations you will likely need

Most applications submitted through Grants.gov need the following. Registration can take several weeks, so start early. The notice lists the exact requirements.

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