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SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)

National Institutes of Health · Opportunity number PAR-27-098

View the official notice on Grants.gov
902 days left (deadline Apr 5, 2029)

Details summarized from the official notice as of Oct 15, 2026. Always confirm eligibility, deadlines and requirements in the official notice before applying.

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Key facts

Opportunity numberPAR-27-098
AgencyNational Institutes of Health
Department of Health and Human Services
Assistance listing (ALN, formerly CFDA)93.307, 93.313, 93.865, 93.838, 93.242, 93.233, 93.273, 93.173, 93.853, 93.393, 93.395, 93.350, 93.866, 93.121, 93.867, 93.113, 93.855, 93.859, 93.172, 93.839, 93.840, 93.286, 93.846, 93.143, 93.351, 93.394, 93.837, 93.847
PostedMay 28, 2026
DeadlineApr 5, 2029
Cost sharing or matching requiredNo
Funding typeGrant
CategoryHealth
Last updated hereOct 15, 2026

Summary from the notice

The Commercialization Readiness Pilot (CRP) program helps small business concerns (SBCs) move NIH-funded SBIR or STTR projects from late-stage development to commercialization. The CRP supports later-stage research and development (R&D) and/or technical assistance that Phase II and Phase IIB Strategic Breakthrough awards do not typically support. This includes:Independent replication or confirmation of key studiesIND- or IDE-enabling studiesClinical studiesManufacturing scale-up and related quality activitiesRegulatory and other specialized technical supportSBCs may subcontract (outsource) a significant amount of the work in a CRP to meet the project goals.

Who can apply

The official notice lists these applicant types as eligible:

  • Small businesses
  • State governments
  • County governments
  • Others named in the notice (see the eligibility text)
  • Other Native American tribal organizations
  • Public and Indian housing authorities
  • Nonprofits without 501(c)(3) status (other than colleges)
  • Special district governments
  • Federally recognized tribal governments
  • Private colleges and universities
  • Public and state colleges and universities
  • Nonprofits with 501(c)(3) status (other than colleges)
  • For-profit organizations other than small businesses
  • City or township governments
  • Independent school districts

Who should take a closer look

  • Small businesses
  • Nonprofits
  • Colleges and universities
  • State governments
  • Local governments
  • Tribal governments and organizations
  • Larger for-profit companies

Not listed as eligible

  • Individuals

Unless the eligibility text in the notice names you, this opportunity is probably not for you.

Eligibility details from the notice

Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir.gov/apply) are eligible to submit applications for this opportunity.Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Unfunded international collaborations or unfunded foreign components, as defined in the NIH Grants Policy Statement, may be allowed.

Registrations you will likely need

Most applications submitted through Grants.gov need the following. Registration can take several weeks, so start early. The notice lists the exact requirements.

Past awards for this program

Totals for assistance listing 93.307, 93.313, 93.865, 93.838, 93.242, 93.233, 93.273, 93.173, 93.853, 93.393, 93.395, 93.350, 93.866, 93.121, 93.867, 93.113, 93.855, 93.859, 93.172, 93.839, 93.840, 93.286, 93.846, 93.143, 93.351, 93.394, 93.837, 93.847 from public USASpending.gov data, as of Mar 26, 2026. Past awards do not predict future funding.

YearListingAwardsTotalAverage
2026 93.855 1 $1,062,954,652 $1,062,954,652

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