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Closed on May 7, 2026

Small R01s for Clinical Trials Targeting Diseases within the Mission of NIDDK (R01 Clinical Trial Required)

National Institutes of Health · Opportunity number PAS-25-102

Details summarized from the official notice as of May 8, 2026. Always confirm eligibility, deadlines and requirements in the official notice before applying.

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This opportunity is closed as of May 7, 2026. It is kept here for reference. See the related open opportunities below, or check the official listing in case the agency posts a new cycle.

Key facts

Opportunity numberPAS-25-102
AgencyNational Institutes of Health
Department of Health and Human Services
Assistance listing (ALN, formerly CFDA)93.847
PostedJan 8, 2025
DeadlineMay 7, 2026
Award ceiling$200,000
Cost sharing or matching requiredNo
Funding typeGrant
CategoryFood and nutrition
Last updated hereMay 8, 2026

Summary from the notice

This Notice of Funding Announcement (NOFO) encourages the submission ofpilot and feasibilityclinical trialsconducted in humans that will lay the foundation for larger clinical trials related to the prevention and/or treatment of diseases and conditions within the mission of NIDDK. The program will support small, short-term proof-of-concept clinical trials in humans to acquire preliminary data regarding the effects of the intervention, as well as feasibility data related to recruitment and retention, and study conduct. Applications for clinical trials submitted under this NOFO should have clearly described aims and objectives and have a high likelihood that the trial findings will lead to more definitive, hypothesis-driven trials to improve understanding, diagnosis, prevention or treatment of the diseases studied and have the potential to impact clinical practice and/or public health.Preliminary data regarding intervention efficacy are not required.

Who can apply

The official notice lists these applicant types as eligible:

  • Private colleges and universities
  • Public and Indian housing authorities
  • Other Native American tribal organizations
  • Small businesses
  • Nonprofits with 501(c)(3) status (other than colleges)
  • Public and state colleges and universities
  • Special district governments
  • State governments
  • Nonprofits without 501(c)(3) status (other than colleges)
  • Others named in the notice (see the eligibility text)
  • For-profit organizations other than small businesses
  • Independent school districts
  • City or township governments
  • Federally recognized tribal governments
  • County governments

Who should take a closer look

  • Small businesses
  • Nonprofits
  • Colleges and universities
  • State governments
  • Local governments
  • Tribal governments and organizations
  • Larger for-profit companies

Not listed as eligible

  • Individuals

Unless the eligibility text in the notice names you, this opportunity is probably not for you.

Eligibility details from the notice

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Registrations you will likely need

Most applications submitted through Grants.gov need the following. Registration can take several weeks, so start early. The notice lists the exact requirements.

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