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Closed on Jun 4, 2026

Impact of Initial Influenza Exposure on Immunity in Infants (U01 Clinical Trial Not Allowed)

National Institutes of Health · Opportunity number RFA-AI-27-019

Details summarized from the official notice as of Jun 5, 2026. Always confirm eligibility, deadlines and requirements in the official notice before applying.

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This opportunity is closed as of Jun 4, 2026. It is kept here for reference. See the related open opportunities below, or check the official listing in case the agency posts a new cycle.

Key facts

Opportunity numberRFA-AI-27-019
AgencyNational Institutes of Health
Department of Health and Human Services
Assistance listing (ALN, formerly CFDA)93.855
PostedFeb 10, 2026
DeadlineJun 4, 2026
Award ceiling$3,000,000
Expected number of awards3
Estimated total program funding$9,600,000
Cost sharing or matching requiredNo
Funding typeCooperative agreement
CategoryHealth
Last updated hereJun 5, 2026

Summary from the notice

The purpose of this notice of funding opportunity (NOFO) is to support the establishment or continuation of longitudinal infant cohorts to determine and compare how initial and repeated natural influenza infections and/or influenza vaccinations shape infant and childhood immunity to future influenza exposures. The goal of this research is to understand how these exposures influence immune responses to subsequent influenza infections and/or vaccines and provide key information to facilitate design of durable, broadly protective influenza vaccines.

Who can apply

The official notice lists these applicant types as eligible:

  • Nonprofits with 501(c)(3) status (other than colleges)
  • City or township governments
  • County governments
  • Public and Indian housing authorities
  • Independent school districts
  • Small businesses
  • State governments
  • Special district governments
  • Private colleges and universities
  • Nonprofits without 501(c)(3) status (other than colleges)
  • Public and state colleges and universities
  • Federally recognized tribal governments
  • Others named in the notice (see the eligibility text)
  • For-profit organizations other than small businesses
  • Other Native American tribal organizations

Who should take a closer look

  • Small businesses
  • Nonprofits
  • Colleges and universities
  • State governments
  • Local governments
  • Tribal governments and organizations
  • Larger for-profit companies

Not listed as eligible

  • Individuals

Unless the eligibility text in the notice names you, this opportunity is probably not for you.

Eligibility details from the notice

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Registrations you will likely need

Most applications submitted through Grants.gov need the following. Registration can take several weeks, so start early. The notice lists the exact requirements.

Past awards for this program

Totals for assistance listing 93.855 from public USASpending.gov data, as of Mar 26, 2026. Past awards do not predict future funding.

YearListingAwardsTotalAverage
2026 93.855 1 $1,062,954,652 $1,062,954,652

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