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GREGoRi Innovation Projects (U01 Clinical Trial Optional)

National Institutes of Health · Opportunity number RFA-HG-27-013

View the official notice on Grants.gov
14 days left (deadline Oct 30, 2026)

Details summarized from the official notice as of Oct 16, 2026. Always confirm eligibility, deadlines and requirements in the official notice before applying.

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Key facts

Opportunity numberRFA-HG-27-013
AgencyNational Institutes of Health
Department of Health and Human Services
Assistance listing (ALN, formerly CFDA)93.172
PostedJun 18, 2026
DeadlineOct 30, 2026
Award ceiling$500,000
Award floor$3
Expected number of awards10
Estimated total program funding$7,500,000
Cost sharing or matching requiredNo
Funding typeCooperative agreement
CategoryHealth
Last updated hereOct 16, 2026

Summary from the notice

The Genomics Research to Elucidate the Genetics of Rare Diseases:innovation (GREGoRi) initiative seeks to accelerate a paradigm shift in rare disease diagnosis by reimagining the tools, molecular technologies and analytical approaches used to identify the causal gene(s) and/or variant(s) underlying rare genetic disorders. This Notice of Funding Opportunity is intended to stimulate the development and testing of highly innovative experimental or computational approaches for rare disease diagnosis, that have the potential to make transformative improvements to the current state of the art.

Who can apply

The official notice lists these applicant types as eligible:

  • Private colleges and universities
  • Small businesses
  • Nonprofits without 501(c)(3) status (other than colleges)
  • State governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Public and Indian housing authorities
  • County governments
  • Special district governments
  • Nonprofits with 501(c)(3) status (other than colleges)
  • Public and state colleges and universities
  • City or township governments
  • Federally recognized tribal governments
  • Others named in the notice (see the eligibility text)
  • Other Native American tribal organizations

Who should take a closer look

  • Small businesses
  • Nonprofits
  • Colleges and universities
  • State governments
  • Local governments
  • Tribal governments and organizations
  • Larger for-profit companies

Not listed as eligible

  • Individuals

Unless the eligibility text in the notice names you, this opportunity is probably not for you.

Eligibility details from the notice

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Registrations you will likely need

Most applications submitted through Grants.gov need the following. Registration can take several weeks, so start early. The notice lists the exact requirements.

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