Open federal grants for nonprofits
472 open opportunities as of Oct 16, 2026.
Independent platform. Not affiliated with or endorsed by any government agency. Data from public federal sources.
Many federal programs list nonprofits as eligible, and notices often split them into two groups: nonprofits with 501(c)(3) status from the IRS and nonprofits without it. Check which group the notice names. Colleges and universities are usually listed separately even when they are nonprofits.
The list below shows every open opportunity in our database whose official notice lists nonprofits as an eligible applicant type. Each listing links to a summary page and to the official notice.
Being in an eligible group is only the first check. Read the eligibility section of each notice for location, program focus, cost sharing and other conditions before you start an application.
Open opportunities
HEAL Initiative: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional)
National Institutes of Health · RFA-DA-27-016
HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
National Institutes of Health · RFA-NS-27-007
NIAMS P30 Centers Program (P30 - Clinical Trial Not Allowed)
National Institutes of Health · RFA-AR-28-001
Research Grants in Clinical Informatics (R01 Clinical Trial Optional)
National Institutes of Health · PAR-26-042
Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional)
National Institutes of Health · PAR-26-040
NINDS Efficacy and Exploratory Clinical Trials (UG3/UH3 - Clinical Trial Required)
National Institutes of Health · PAR-27-065
Paul Calabresi Career Development Award for Clinical Oncology (K12 Clinical Trial Not Allowed)
National Institutes of Health · PAR-27-025
Science Track Award for Research Transition (START) Program (R03, Clinical Trial Optional)
National Institutes of Health · PAS-27-028
SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)
National Institutes of Health · PAR-27-098
Predoctoral to Postdoctoral Transition Award (Parent F99/K00 - Clinical Trial Not Allowed)
National Institutes of Health · PA-27-037
NIH Brain Development Cohorts (NBDC) and Population Assessment of Tobacco and Health (PATH) Study Biospecimen Access (X01 Clinical Trial Not Allowed)
National Institutes of Health · PAR-27-051
NIH Research Educational Program - Mentoring Activities & Networks (Parent R25/UE5 - Clinical Trial Not Allowed)
National Institutes of Health · PA-27-035
NIH Research Education Program - Research Experiences (Parent R25 - Clinical Trial Not Allowed)
National Institutes of Health · PA-27-036
NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional)
National Institutes of Health · PA-26-002
Biological Testing Facility for Contraception & Reproductive Health (X01 Clinical Trial Not Allowed)
National Institutes of Health · PAR-27-111
NIH Science Education Partnership Award (SEPA) (R25 - Clinical Trial Not Allowed)
National Institutes of Health · PAR-27-077
NIAID Resource-Related Research Projects (R24 Clinical Trial Not Allowed)
National Institutes of Health · PAR-27-083
NIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed)
National Institutes of Health · PAR-27-082
NIH Research Education Program - Courses, Curriculum & Methods (Parent R25 - Clinical Trial Not Allowed)
National Institutes of Health · PA-27-034
Limited Competition: Centers of Biomedical Research Excellence: Expansion/Sustainability Phases (COBRE-E/S) (P30 - Clinical Trial Not Allowed)
National Institutes of Health · PAR-27-055
Frequently asked questions
Does being listed as eligible mean my organization qualifies?
No. The applicant type is only the first filter. Most notices add more conditions, such as location, program focus, matching funds or prior experience. Read the eligibility section of the official notice before you apply.
Is GovGrantsUSA a government website?
No. GovGrantsUSA is an independent platform operated by VRLY Ventures LLC. It is not affiliated with or endorsed by any government agency. Opportunity details are summarized from public federal sources such as Grants.gov.
Does it cost anything to apply for a federal grant?
Searching for and applying to federal grants on Grants.gov is free. Be wary of anyone who asks for a fee to "release" a grant or guarantees an award.
How current is this information?
Listings are refreshed from public federal data every day, and each page shows when it was last updated. Agencies can change or cancel a notice at any time, so always confirm details in the official notice.
What do I need before I can apply?
Most applicants through Grants.gov need an active SAM.gov registration with a Unique Entity ID (UEI), a Login.gov account and a Grants.gov account linked to their organization. Registration can take several weeks, so start early.