Open federal grants for nonprofits
472 open opportunities as of Oct 16, 2026.
Independent platform. Not affiliated with or endorsed by any government agency. Data from public federal sources.
Many federal programs list nonprofits as eligible, and notices often split them into two groups: nonprofits with 501(c)(3) status from the IRS and nonprofits without it. Check which group the notice names. Colleges and universities are usually listed separately even when they are nonprofits.
The list below shows every open opportunity in our database whose official notice lists nonprofits as an eligible applicant type. Each listing links to a summary page and to the official notice.
Being in an eligible group is only the first check. Read the eligibility section of each notice for location, program focus, cost sharing and other conditions before you start an application.
Open opportunities
INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed)
National Institutes of Health · RFA-OD-27-003
INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)
National Institutes of Health · RFA-OD-27-004
INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required)
National Institutes of Health · RFA-OD-27-005
Exploratory Clinical Neuroscience Research on Substance Use Disorders (R61/R33 Clinical Trial Optional)
National Institutes of Health · PAR-27-053
BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program - iBCP (RM1 Clinical Trial Not Allowed)
National Institutes of Health · RFA-NS-27-002
Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed)
National Institutes of Health · PAR-27-021
Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)
National Institutes of Health · PAR-27-022
Lasker Clinical Research Scholar's Program (Si2/R00 Clinical Trial Optional)
National Institutes of Health · PAR-27-076
Grants for Early Medical/Surgical Specialists' Transition to Aging Research (GEMSSTAR) (R03 Clinical Trial Optional)
National Institutes of Health · PAR-27-096
Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R21 Clinical Trial Not Allowed)
National Institutes of Health · PAR-25-450
Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)
National Institutes of Health · PAR-25-446
Transformative Non-Invasive/Minimally Invasive Technologies for Imaging the Olfactory System Across Scales (R01 CT Optional)
National Institutes of Health · RFA-DC-27-003
Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)
National Institutes of Health · PAR-25-322
Vet-LIRN Capacity-Building Project and Equipment Grants (U18)
Food and Drug Administration · PAR-23-202
Exploratory Grants in Cancer Control (R21 Clinical Trial Optional)
National Institutes of Health · PA-25-253
Method to Extend Research in Time (MERIT) Award Extension Request (Type 4 eSubmission Clinical Trial Optional)
National Institutes of Health · PAR-25-324
NIGMS Institutional Biomedical Undergraduate Research Training (BURT) Program (T34)
National Institutes of Health · PAR-26-033
Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional)
National Institutes of Health · PAR-25-444
Avant Garde/Avenir Awards for Investigators Conducting High Risk/High Reward Research on HIV and Substance Use (or Substance Use Disorders) (DP1 Clinical Trial Optional)
National Institutes of Health · PAR-27-026
Animal and Biological Material Resource Centers (P40 Clinical Trial Not Allowed)
National Institutes of Health · RFA-OD-25-011
Frequently asked questions
Does being listed as eligible mean my organization qualifies?
No. The applicant type is only the first filter. Most notices add more conditions, such as location, program focus, matching funds or prior experience. Read the eligibility section of the official notice before you apply.
Is GovGrantsUSA a government website?
No. GovGrantsUSA is an independent platform operated by VRLY Ventures LLC. It is not affiliated with or endorsed by any government agency. Opportunity details are summarized from public federal sources such as Grants.gov.
Does it cost anything to apply for a federal grant?
Searching for and applying to federal grants on Grants.gov is free. Be wary of anyone who asks for a fee to "release" a grant or guarantees an award.
How current is this information?
Listings are refreshed from public federal data every day, and each page shows when it was last updated. Agencies can change or cancel a notice at any time, so always confirm details in the official notice.
What do I need before I can apply?
Most applicants through Grants.gov need an active SAM.gov registration with a Unique Entity ID (UEI), a Login.gov account and a Grants.gov account linked to their organization. Registration can take several weeks, so start early.